Buccal patches are a promising dosage form for both local and
systemic delivery of active substances in the oral cavity. This
Master’s thesis focuses on the development of buccal patches
with a polymer matrix based on hydrophobized hyaluronic acid
(HA), which incorporates polymer nanoparticles composed of
hydrophobized HA with an encapsulated active substance with
antioxidant effect.
The work aimed to prepare and characterize these systems with a
focus on identifying the impact of the molecular weight of
hydrophobized and native HA, as well as the presence of salts,
on the resulting properties of the polymer matrix. For these
purposes, the mucoadhesion time, drug release kinetics,
antimicrobial activity, cytotoxicity and swelling behavior of
the patches and the degree of active substance penetration into
the buccal mucosa was evaluated. The internal structure of the
patches was analyzed using scanning electron microscopy.
The results of this work may serve as a foundation for further
development of advanced mucoadhesive systems that will offer a
more effective and comfortable method for drug administration
in the treatment of oral cavity diseases.