aVLBC0422s Biochemie II - seminář

Lékařská fakulta
jaro 2027
Rozsah
0/3/0. 45. 3 kr. Ukončení: z.
Vyučováno kontaktně
Vyučující
doc. RNDr. Jiří Dostál, CSc. (cvičící)
prof. RNDr. Eva Táborská, CSc. (cvičící)
doc. RNDr. Josef Tomandl, Ph.D. (cvičící)
Iva Audy (pomocník)
Mgr. Jana Gregorová, Ph.D. (pomocník)
MUDr. Michaela Králíková, Ph.D. (pomocník)
RNDr. Hana Paulová, CSc. (pomocník)
doc. Mgr. Ondřej Peš, Ph.D. (pomocník)
Mgr. Jiří Slanina, Ph.D. (pomocník)
Mgr. Marie Tomandlová, Ph.D. (pomocník)
Garance
doc. RNDr. Josef Tomandl, Ph.D.
Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Kontaktní osoba: MUDr. Michaela Králíková, Ph.D.
Dodavatelské pracoviště: Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Předpoklady
aVLBC0321s Biochemistry I - seminar && aVLFY0321c Fyziologie I - cv. && aVLFY0321s Fyziologie I - sem.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Anotace
The seminars complement the lecture-based course Biochemistry II and focus on practising and applying key biochemical principles. Their aim is to deepen students’ understanding of intermediary metabolism and its regulation under various physiological and pathological conditions, to clarify the metabolic characteristics of individual organs and tissues, and to consolidate the principles of maintaining homeostasis, including acid–base balance. The instruction emphasises problem‑solving, interpretation of laboratory results, and linking biochemical concepts with clinical practice.
Výstupy z učení
Upon successful completion of the seminars, the student will be able to:
  • explain the interrelationships between nutrient metabolism in different physiological and pathological states;
  • describe the metabolic characteristics of major organs and tissues and discuss their disorders in relation to diseases;
  • understand and apply the principles of homeostasis and acid–base balance when solving model clinical situations;
  • discuss the composition of body fluids and their changes in the context of homeostatic disturbances;
  • explain the principles of metabolic regulation at the molecular, cellular, and systemic levels.
Klíčová témata
  • Enzymes in clinical diagnostics. Methods in clinical biochemistry. Analysers and POCT systems.
  • Blood glucose. Protein metabolism. Proteins in nutrition. Transport forms of ammonia.
  • Lipoproteins and their metabolism. Cholesterol transport and daily turnover.
  • Interrelations of major metabolic pathways in different physiological states. Malnutrition, obesity, metabolic syndrome, and stress metabolism.
  • Liver functions. Role of the liver in nutrient metabolism. Heme catabolism, hyperbilirubinaemia.
  • Hepatic metabolism of hormones and vitamins. Iron metabolism. Xenobiotic biotransformation. Alcohol metabolism.
  • Internal environment: homeostasis of water and ions (Na⁺, K⁺), osmolality, regulation, and disorders.
  • Acid–base balance: parameters, regulation, disorders. Buffer systems. Transport of O₂ and CO₂.
  • Kidney function: glomerular filtration, tubular reabsorption, and secretion. Diuretics.
  • Receptors for neurotransmitters and hormones. Major signalling pathways.
  • Steroid and thyroid hormones.
  • Biochemistry of muscle function. Effects of nitric oxide. Energetics of muscle work.
  • Metabolism of calcium, magnesium, phosphates, fluoride, and iodine.
  • Extracellular matrix. Metabolism of connective tissue and skin. Bone markers.
Studijní zdroje a literatura
    povinná literatura
  • Interactive Syllabus of the course in IS MU.
  • RODWELL, Victor W.; David A. BENDER; Kathleen M. BOTHAM; Peter J. KENNELLY a P. Anthony WEIL. Harper's illustrated biochemistry. Thirty-first edition. New York: McGraw-Hill, 2018, x, 789. ISBN 9781260288421. info
    doporučená literatura
  • LIEBERMAN, Michael; Allan D. MARKS a Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
  • Recommended literature from medical physiology in the course aVLFY0422p.
Přístupy, postupy a metody používané ve výuce
Seminar‑based instruction focused on the discussion of assigned topics and the solution of model examples.
Způsob ověření výstupů z učení a požadavky na ukončení
Credit. Conditions for giving the course-unit credit:
1) completion of all seminars and 2) completion of in-term tests.
Vyučovací jazyk
Angličtina
Odkaz a informace vyučujících

Detailed information on the organisation, teaching methods, and completion requirements of the course is available in the Study Materials section of the IS MU.

Consultation is possible upon personal arrangement with the teacher.

Další komentáře
Předmět je vyučován každoročně.
Výuka probíhá každý týden.
Successful completion of the course is a condition for access to the exam in the course aVLBC0422p.
Nachází se v prerekvizitách jiných předmětů
Předmět je zařazen také v obdobích jaro 2017, jaro 2018, jaro 2019, jaro 2020, jaro 2021, jaro 2022, jaro 2023, jaro 2024, jaro 2025, jaro 2026.