FDBOa_FAF Bioorganic Chemistry

Farmaceutická fakulta
jaro 2026
Rozsah
2/0/0. 5 kr. Ukončení: zk.
Vyučováno kontaktně
Vyučující
doc. PharmDr. Oldřich Farsa, Ph.D. (přednášející)
Garance
doc. PharmDr. Oldřich Farsa, Ph.D.
Farmaceutická fakulta
Dodavatelské pracoviště: Ústav chemických léčiv – Ústavy – Farmaceutická fakulta
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Anotace
Bioorganic chemistry is chemistry of organic biologically active compounds. It is besides medicines which are in detail studied by medicinal chemistry concerned with pesticides used in agriculture (herbicides, fungicides, insecticides, moluscocides, rodenticides...), food additives in which a biologic activity can be specified, chemical warfare agents and toxic compounds of all the kind. The discipline studies both qualitative (SAR) a quantitative (QSAR) relationships between structure and activity or toxicity of these compounds. It also deals with their syntheses and metabolism as well as computer modelling of interactions of these molecules with target structures such as such as active sites of enzymes, receptors or nucleic acids.
Výstupy z učení
A DSP student will acquire an advanced knowledge in the field of biologically active compounds, which cannot considered to be medicines, mainly pesticides, chemical assault substances, industrial poisons and food additives in the range, agreed preliminarily among a student, his/her tutor and a examiner.
Klíčová témata
Topics:
1. Compounds interacting with the vegetative nervous system. Indirect cholihergics - choline esterases inhibitors: insecticides, warfare agents. Choline esterases reactivators. Specific GABA-receptors´ subtypes ligands: insecticides.
2. Anticoagulants. Rodenticides.
3. Herbicides. Photosynthesis inhibitors and compounds acting by other mechanisms.
4. Antimicrobial and antifungal preservatives of foods, drug forms, cosmetics, wood and agricultular fungicides.
5. Antioxidants for food, pharmaceutical, cosmetic and industrial usage.
6. Repelents.
Studijní zdroje a literatura
    doporučená literatura
  • Lushchak V.I., Matviishyn T.M. et al. Pesticide toxicity: a mechanistic approach. Germany, 2018. URL info
  • Tarazona J.V., Court-Marques D. et al. Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC. Germany, 2017. info
  • Abou-Donia M.B., Siracuse B., Gupta N., Sobel Sokol A. Sarin (GB, O-isopropyl methylphosphonofluoridate) neurotoxicity: critical review. England, 2016. info
  • Ulrich E.M., Morrison C.N. et al. Chiral pesticides: identification, description, and environmental implications. Unites States, 2012. info
  • Hoskovcová M, Halámek E, Kobliha Z. Study of efficacy of reactivator HI 6 in reactivation of immobilized acetylcholinesterase, inhibited by organophosphorus chemical warfare agents of the "G" series. United Arab Emirates, 2009. info
  • Rowe R. et al. Handbook of pharmaceutical excipients. London, 2005. info
  • Buckingham S.D., Biggin P.C. et al. Insect GABA receptors: splicing, editing, and targeting by antiparasitics and insecticides. 2005. info
  • Schmidt R. H., Rodrich G. e. Food Safety Handbook. 2003. ISBN 9780470362570. info
Přístupy, postupy a metody používané ve výuce
Methods of work with a text (a textbook, a book, journal articles via internet)
Způsob ověření výstupů z učení a požadavky na ukončení
Ústní zkouška
Vyučovací jazyk
Angličtina
Předmět je zařazen také v obdobích jaro 2025, podzim 2025.
  • Statistika zápisu (nejnovější)
  • Permalink: https://is.muni.cz/predmet/pharm/jaro2026/FDBOa_FAF