aFAGE1_16 Applied Genetics

Farmaceutická fakulta
jaro 2026

Předmět se v období jaro 2026 nevypisuje.

Rozsah
2/0/0. 28p. 3 kr. Ukončení: zk.
Vyučující
prof. MVDr. RNDr. Petr Hořín, CSc. (přednášející)
PharmDr. Mgr. Alžběta Kružicová, Ph.D. (přednášející)
Garance
prof. MVDr. RNDr. Petr Hořín, CSc.
Ústav molekulární farmacie – Ústavy – Farmaceutická fakulta
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Anotace
Theoretical principles and practical applications of genetics in pharmacy are taught. Special attention is paid to genomics and its importance for new drug development, to genetics of disease, geentics of host and pathogen interactions, genetic variability in reactions to pharmacotherapy. Genetics of laboratory animals represents a special topic of the course.
Výstupy z učení
Students will be able to use the acquired knowledge in related curricular subjects and eventually, they will be able to use it in understanding principles of drug action and in interpreting them for themselves and for their clients.
Klíčová témata
1. Genome and its structure. Microbiome and its importance for pharmacy.Genetic polymorphism: definition, origins, types and practical applications in biomedicine. 2. Gene and methods of its identification. Genetics of qualitative and quantitative traits, methods of their analysis; applications in biomedicine. 3. Application of genetics in pharmacy: pharmacogenetics, important pharmacogenetic polymorphisms and applications in pharmacotherapy. 4. Genomics and its applications in pharmacy: pharmacogenomics, development of new drugs, precision medicine. 5. Mutations and mutagens. Types of mutations, their consequences. Mutagens in the environment. Drugs as potential mutagens. 6. Drugs in pregnancy from the genetic perspective. 7. Inherited disease in humans: Mendelian and non-Mendelian diseases. Human monogeneic diseases: modes of inheritance. 8. Inherited disease in humans: complex diseases and their genetic analysis. 9. Inherited disease in humans: genetic counselling, genetic diagnostics, prenatal and preimplantation diagnostics. 10. Oncogenetics: principles and applications. 11. Genetic susceptibility to disease, importance for precision medicine. 12. Human immunogenetics and its applications. Vaccinomics and genetics of vaccination. 13. Genetics of laboratory animals.
Studijní zdroje a literatura
    doporučená literatura
  • PIERCE, Benjamin A. Genetics : a conceptual approach. Seventh edition. New York: Macmillan international, higher education, 2020, xxviii, 82. ISBN 9781319308315. info
Přístupy, postupy a metody používané ve výuce
Interactive lectures.
Způsob ověření výstupů z učení a požadavky na ukončení
Written examinations. Assessment criteria: capability to present an overview of a topic in a structured way, capability to explain its principles and a minimal factographic knowledge neede for complying with the previous criteria.
Vyučovací jazyk
Angličtina
  • Permalink: https://is.muni.cz/predmet/pharm/jaro2026/aFAGE1_16